2021年考研南京医科大学药学院接收调剂研究生的通知
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课题组负责人简介:
教育经历:
2013-2018 中国科学院广州生物医药与健康研究院 博士(硕博连读)
2018-2020 威斯康星大学麦迪逊分校 药学院 博士后
2020-至今 南京医科大学 药学院 课题组长
研究方向:
1.肿瘤、心脑血管等疾病的小分子药物开发
2.基于蛋白质组学的靶标发现鉴定
3.人工智能药物筛选
代表性论文(#共同作者,*通讯作者):
zhu d#.; guo h#.; chang y#.; ni y.; li l.; hao. p*.; xu y.; ding k*.; li z*. cell- and tissue-based proteome profiling and dual imaging of apoptosismarkers with probes derived from venetoclax and idasanutlin. angew. chem. int. edt. 2018, 57, 9284╟9289
zhu d#.; huang h#.; pinkas d#.; luo j.; ganguly d.; fox a.; arner e.; xiang q.; tu. z.; bullock a*.; brekken. r*.; ding k*.; lu x*. 2-amino-2,3-dihydro-1h-indene-5-carboxamide-based discoidin domain receptor 1 (ddr1) inhibitors: design, synthesis, and in vivo antipancreatic cancer efficacy. j. med. chem. 2019, 62, 7431-7444
estevez a#.; zhu d#.; blankenship c.; jiang j*. molecular interrogation to crack the case of o-glcnac. chemistry ╟ a european journal, 2020, doi.org/10.1002/chem.202000155
chang y#.; zhu d#.; guo h#.; yin x.; ding k.; li z*. crenolanib‐derived probes suitable for cell‐and tissue‐based protein profiling and single‐cell imaging. chembiochem, 2019, 20, 1783-1788
worth m#.; hu c#.; li h.; fan d.; estevez a.; zhu d.; wang a.; jiang j*. targeted covalent inhibition of o-glcnac transferase in cells. chem commun. 2019, 55, 13291-13294
wang z#.; zhang y#.; pinkas d#.; fox a.; luo j.; huang h.; cui s.; xiang q.; xu t.; xun q.; zhu d.; tu z.; ren x.; brekken r.; bullock a.; liang g*.; ding k*.; lu x*. design, synthesis, and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-n-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a dual inhibitor of discoidin domain receptors 1 and 2. j. med. chem. 2018, 61, 7977-7990